Le Cholera
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regions there. The rapid methods of orientation employed by certain observers are entirely to be deprecated, he considers: for if their result be negative, further investigation must be done, and if it be positive, it requires confirmation. Thus they do not save time, as their users profess to believe. Whenever there is reason to suspect that a case of cholera has occurred, the bacteriologist should carry out
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Individuals with Le(a+b−) Blood Group Have Increased Susceptibility to Symptomatic Vibrio cholerae O1 Infection
BACKGROUND Human genetic factors such as blood group antigens may affect the severity of infectious diseases. Presence of specific ABO and Lewis blood group antigens has been shown previously to be associated with the risk of different enteric infections. The aim of this study was to determine the relationship of the Lewis blood group antigens with susceptibility to cholera, as well as severity...
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Following the landfall of Hurricane Matthew in Haiti on October 3, 2016, an increase of suspected cholera cases was reported in both the southern part of the island (with Grande-Anse and Le Sud departments reporting 1349 and 1533 cases respectively between 5 October and 6 November) and also in the capital, Port-au-Prince (438 cases reported over the same period) [1]. The hurricane caused the di...
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Vibrio cholerae, a Gram-negative pathogen autochthonous to the aquatic environment, is the causative agent of cholera. Here, we report the complete genome sequence of V. cholerae G4222, a clinical isolate from South Africa.
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Cholera toxin is associated with caveolae and raft domains in various cell types and previous studies have shown that cholera toxin can be internalized by caveolae/raft-dependent endocytosis as well as by other pathways. We undertook the study of cholera toxin endocytosis in CaCo-2 and HeLa cells. CaCo-2 cells do not express detectable levels of caveolin and, relative to HeLa cells, also presen...
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